Hydrazine hydrate (1:1) → HCID 178456518、化合物

HRID 29873ノート

反応式

HRID 29873 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][N:12]2[C:20]3[N:19]=[C:18]([CH2:21][C:22]4[NH:26][N:25]=[N:24][N:23]=4)[NH:17][C:16]=3[C:15](=[O:27])[N:14]([CH2:28][CH2:29][CH3:30])[C:13]2=[O:31])=[CH:6][CH:5]=1)([O-])=O.O.NN.[H][H]>[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][N:12]2[C:20]3[N:19]=[C:18]([CH2:21][C:22]4[NH:26][N:25]=[N:24][N:23]=4)[NH:17][C:16]=3[C:15](=[O:27])[N:14]([CH2:28][CH2:29][CH3:30])[C:13]2=[O:31])=[CH:6][CH:5]=1

参加物

5

反応物 3

HCID 24654Hydrazine hydrate (1:1)HCID 178418361HCID 178418361、化合物HCID 178456519HCID 178456519、化合物

生成物 1

HCID 178456518HCID 178456518、化合物

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

実験手順

By the method of Example 2, 1H-tetrazole-5-acetic acid is reacted with 5,6-diamino-1-[2-(4-nitrophenyl)ethyl]-3-propyluracil (6) to yield 3-[2-(4-nitrophenyl)ethyl]-1-propyl-8-[(1H-tetrazol-5-yl)methyl]xanthine. By methods well known in the art, 3-[2-(4-nitrophenyl)ethyl]-1-propyl-8-[(1H-tetrazol-5-yl)methyl]xanthine is reduced with hydrazine hydrate or hydrogen gas in the presence of a palladium catalyst to yield 3-[2-(4-aminophenyl)ethyl]-1-propyl-8-[(1H-tetrazol-5-yl)methyl]xanthine.

出典と根拠

ORDレコード
ord-321e5939a8ca472e83215be589f50f7b
出典データセット
uspto-grants-2008_09
特許番号
US07423041B2

反応ノート

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