Sodium Carbonate → (+/-)-1-(Oxiranylmethyl)-2,4-imidazolidinedione

HRID 30091

反応式

HRID 30091 の反応式
[CH2:1]([N:4]1[CH2:8][C:7](=[O:9])[NH:6][C:5]1=[O:10])[CH:2]=[CH2:3].ClC1C=C(C(OO)=[O:19])C=CC=1.S(=O)(O)[O-].C([O-])([O-])=O.[Na+].[Na+]>C(Cl)Cl>[O:19]1[CH2:3][CH:2]1[CH2:1][N:4]1[CH2:8][C:7](=[O:9])[NH:6][C:5]1=[O:10]

参加物

6

反応物 4

HCID 10340Sodium CarbonateHCID 70297m-Chloroperbenzoic acidHCID 104748BisulfiteHCID 220209241-(Prop-2-en-1-yl)imidazolidine-2,4-dione

生成物 1

HCID 22020929(+/-)-1-(Oxiranylmethyl)-2,4-imidazolidinedione収率 89%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A reaction solution of 1-(2-propenyl)-2,4-imidazolidinedione (0.036 mol) and 3-chloro-benzenecarboperoxoic acid (0.043 mol, 70.75%) in DCM (25 ml) was stirred for 2 hours at room temperature. An aqueous solution of bisulfite was added and the mixture was stirred for 10 minutes. Na2CO3 was added and this mixture was extracted with DCM. The separated organic layer was dried, filtered and the solvent evaporated, yielding 5 g of (±)-1-(oxiranylmethyl)-2,4-imidazolidinedione (intermediate 18).

後処理

  1. extractionthis mixture was extracted with DCM
  2. customThe separated organic layer was dried
  3. filtrationfiltered
  4. customthe solvent evaporated

出典と根拠

ORDレコード
ord-2d6311f3fe124212b3572c7a948ab5ac
出典データセット
uspto-grants-2008_09
特許番号
US07423048B2

関連ノート

読み込み中…