Acetonitrile → METHYL (2S)-PYRROLIDIN-2-YLACETATE

HRID 30190

反応式

HRID 30190 の反応式
[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][C@H:9]1[CH2:13][C:14]([OH:16])=[O:15])=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:17](#N)C.C(N(CC)C(C)C)(C)C.C[Si](C=[N+]=[N-])(C)C>CO.C(OCC)(=O)C>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][C@H:9]1[CH2:13][C:14]([O:16][CH3:17])=[O:15])=[O:7])([CH3:4])([CH3:2])[CH3:3]

参加物

7

反応物 4

HCID 6342AcetonitrileHCID 81531DiisopropylethylamineHCID 167693TrimethylsilyldiazomethaneHCID 688605(S)-2-(1-BOC-2-pyrrolidinyl)acetic acid

生成物 1

HCID 11075654METHYL (2S)-PYRROLIDIN-2-YLACETATE

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

A solution of (S)-2-carboxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester (2.00 g) in methanol (1.32 ml)/acetonitrile (40 ml) was treated with N,N-diisopropylethylamine (1.78 ml). Trimethylsilyldiazomethane, (2M, 8.73 ml) was added dropwise and the resulting mixture was stirred at room temperature, under argon for 24 h. The mixture was diluted with ethyl acetate, washed with 2M HCl, saturated aqueous sodium hydrodgen carbonate, brine then dried (magnesium sulfate). The solvent was removed under reduced pressure to afford the title compound (2.10 g)

後処理

  1. washwashed with 2M HCl, saturated aqueous sodium hydrodgen carbonate, brine
  2. dry with materialthen dried (magnesium sulfate)
  3. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-4e1436db5cc14e1e913b2f5e0d983284
出典データセット
uspto-grants-2008_09
特許番号
US07423052B2

関連ノート

読み込み中…