Methanol → 5-[1-(4-Amino-phenyl)-ethylcarbamoyl]-thiophene-2-carboxylic acid methyl ester

HRID 30235ノート

反応式

HRID 30235 の反応式
[CH3:1][O:2][C:3]([C:5]1[S:6][C:7]([C:10](=[O:23])[NH:11][CH:12]([C:14]2[CH:19]=[CH:18][C:17]([N+:20]([O-])=O)=[CH:16][CH:15]=2)[CH3:13])=[CH:8][CH:9]=1)=[O:4].CO>[Pd].C1COCC1>[CH3:1][O:2][C:3]([C:5]1[S:6][C:7]([C:10](=[O:23])[NH:11][CH:12]([C:14]2[CH:15]=[CH:16][C:17]([NH2:20])=[CH:18][CH:19]=2)[CH3:13])=[CH:8][CH:9]=1)=[O:4]

参加物

5

反応物 2

HCID 887MethanolHCID 691350675-[1-(4-Nitro-phenyl)-ethylcarbamoyl]-thiophene-2-carboxylic acid methyl ester

生成物 1

HCID 691350895-[1-(4-Amino-phenyl)-ethylcarbamoyl]-thiophene-2-carboxylic acid methyl ester

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of 500 mg (1.497 mmol) 5-[1-(4-Nitro-phenyl)-ethylcarbamoyl]-thiophene-2-carboxylic acid methyl ester, 200 mg palladium on charcoal (10%), 10 ml methanol and 5 ml THF was hydrogenated at 30 mbar for 3 h. The catalyst was filtered off, the solvent was evaporated to give 5-[1-(4-amino-phenyl)-ethylcarbamoyl]-thiophene-2-carboxylic acid methyl ester.

後処理

  1. filtrationThe catalyst was filtered off
  2. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-5f10a87577de4744a4a01bec0963bec2
出典データセット
uspto-grants-2008_09
特許番号
US07423060B2

反応ノート

読み込み中…