N,N,N',N',N'',N''-Hexamethylmethanetriamine → (S)-5-diethylcarbamoyl-4-((E)-2-dimethylamino-vinyl)-5-ethyl-2-oxo-2,5-dihydro-furan-3-carboxylic acid ethyl ester

HRID 30496

反応式

HRID 30496 の反応式
[CH2:1]([O:3][C:4]([C:6]1[C:7](=[O:21])[O:8][C@@:9]([C:14](=[O:20])[N:15]([CH2:18][CH3:19])[CH2:16][CH3:17])([CH2:12][CH3:13])[C:10]=1[CH3:11])=[O:5])[CH3:2].C[C@H]1C[C@@H](OC(=O)C(=O)CC)[C@H](C(C)(C2C=CC=CC=2)C)CC1.[CH3:45][N:46]([CH:48](N(C)C)N(C)C)[CH3:47]>CN(C)C=O>[CH2:1]([O:3][C:4]([C:6]1[C:7](=[O:21])[O:8][C@@:9]([C:14](=[O:20])[N:15]([CH2:16][CH3:17])[CH2:18][CH3:19])([CH2:12][CH3:13])[C:10]=1/[CH:11]=[CH:45]/[N:46]([CH3:48])[CH3:47])=[O:5])[CH3:2]

参加物

5

反応物 3

HCID 79831N,N,N',N',N'',N''-HexamethylmethanetriamineHCID 110883962-oxo-butyric acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl esterHCID 11687992(S)-5-diethylcarbamoyl-5-ethyl-4-methyl-2-oxo-2,5-dihydro-furan-3-carboxylic acid ethyl ester

生成物 1

HCID 11523197(S)-5-diethylcarbamoyl-4-((E)-2-dimethylamino-vinyl)-5-ethyl-2-oxo-2,5-dihydro-furan-3-carboxylic acid ethyl ester

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

According to the procedure described in Example 6 1.22 0 g of compound (23) as obtained from example 17 (4.103 mmol) in 7.3 mL dimethyl formamide were treated with 7.55 mL tris(dimethylamino)methane (42.26 mmol, 10.3 eq) yielding the crude product as an orange oil (1.463 mg, 101% by weight).

出典と根拠

ORDレコード
ord-bbd7d798654d40d2a16d1a5d7de0ddf3
出典データセット
uspto-grants-2008_09
特許番号
US07423152B2

関連ノート

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