Ammonium formate → Gabapentin Enacarbil

To a stirred suspension of ammonium formate (3.4 g, 54 mmol) in ethanol (34 mL), was added compound (15) (10 g, 27 mmol) together with 10% Pd/C (1 g) under a nitrogen atmosphere. After one hour, the reaction mixture was filtered and the catalyst washed with ethanol (2×10 mL). The filtrates were combined and evaporated. The crude product was dissolved in diethyl ether (150 mL) and the organic phase was washed with 2N HCl (100 mL), water (100 mL) and brine (100 mL). The ether layer was dried over anhydrous sodium sulfate and concentrated to give a viscous liquid that crystallized upon standing. The product was recrystallized using 1:10 ethyl acetate:heptane (100 mL) to give the product (11) as a white, crystalline solid (7.9 g, 88%), m.p 63-64° C.

1. filtrationthe reaction mixture was filtered
2. washthe catalyst washed with ethanol (2×10 mL)
3. customevaporated
4. dissolutionThe crude product was dissolved in diethyl ether (150 mL)
5. washthe organic phase was washed with 2N HCl (100 mL), water (100 mL) and brine (100 mL)
6. dry with materialThe ether layer was dried over anhydrous sodium sulfate
7. concentrationconcentrated
8. customto give a viscous liquid that
9. customcrystallized
10. customThe product was recrystallized

ORDレコード

ord-191ae72a0ffa4cf7a192af7f165a1881

出典データセット

uspto-grants-2008_09

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07423169B2