Diglycolamine → N-(2-hydroxyethoxyethyl)hexahydrophthalimide

HRID 3068

反応式

HRID 3068 の反応式
[NH2:1][CH2:2][CH2:3][O:4][CH2:5][CH2:6][OH:7].[C:8]1(=O)[O:13][C:11](=[O:12])[CH:10]2[CH2:14][CH2:15][CH2:16][CH2:17][CH:9]12>C(O)C>[OH:7][CH2:6][CH2:5][O:4][CH2:3][CH2:2][N:1]1[C:11](=[O:12])[CH:10]2[CH2:14][CH2:15][CH2:16][CH2:17][CH:9]2[C:8]1=[O:13]

参加物

4

反応物 2

HCID 13578DiglycolamineHCID 85689Hexahydrophthalic anhydride

生成物 1

HCID 55023972N-(2-hydroxyethoxyethyl)hexahydrophthalimide収率 96%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A 500-ml, two necked flask was equipped with a magnetic stirring bar, heating mantle and condenser. The flask was charged with 51 g of 2-(aminoethoxy) ethanol (0.49 mol.) and 250 ml of ethanol. Next, 75 g of hexahydrophthalic anhydride (0.49 mol.) was slowly added to the flask. After the addition was complete the reaction was refluxed for 12 hours. The IR spectrum indicated the reaction was complete. The ethanol was removed with a rotoevaporator to yield 113 g (96%) of N-(2-hydroxyethoxyethyl)hexahydrophthalimide.

後処理

  1. customA 500-ml, two necked flask was equipped with a magnetic stirring bar
  2. temperatureheating mantle and condenser
  3. additionAfter the addition
  4. temperaturewas refluxed for 12 hours
  5. customThe ethanol was removed with a rotoevaporator

出典と根拠

ORDレコード
ord-0a1e984cbfd144cd8fa2cccd3f2e67f2
出典データセット
uspto-grants-1998_03
特許番号
US05733648

関連ノート

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