Ethanolamine → 4-[4-(4-Fluoro-phenyl)-piperidin-1-yl]-2-(2-hydroxy-ethylamino)-6-(2,2,2-trifluoro-ethoxy)-pyrimidine-5-carbonitrile

反応式

[Cl:1][c:2]1[cH:3][cH:4][cH:5][c:6]([C:7]([O:8][OH:9])=[O:10])[cH:11]1.[F:12][c:13]1[cH:14][cH:15][c:16]([CH:19]2[CH2:20][CH2:21][N:22]([c:25]3[n:26][c:27]([S:39]([CH3:40])(=[O:41])=[O:42])[n:28][c:29]([O:33][CH2:34][C:35]([F:36])([F:37])[F:38])[c:30]3[C:31]#[N:32])[CH2:23][CH2:24]2)[cH:17][cH:18]1.[NH2:43][CH2:44][CH2:45][OH:46].[O:47]1[CH2:48][CH2:49][O:50][CH2:51][CH2:52]1>>[F:12][c:13]1[cH:14][cH:15][c:16]([CH:19]2[CH2:20][CH2:21][N:22]([c:25]3[n:26][c:27]([NH:43][CH2:44][CH2:45][OH:46])[n:28][c:29]([O:33][CH2:34][C:35]([F:36])([F:37])[F:38])[c:30]3[C:31]#[N:32])[CH2:23][CH2:24]2)[cH:17][cH:18]1