Diethyl Sulfate → 2-Bromophenetole

HRID 31343

反応式

HRID 31343 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].S(OCC)(O[CH2:13][CH3:14])(=O)=O>[OH-].[Na+]>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH2:13][CH3:14]

参加物

4

反応物 2

HCID 6163Diethyl SulfateHCID 72442-Bromophenol

生成物 1

HCID 685002-Bromophenetole

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

実験手順

A mixture of 17.5 g of 2-bromophenol, 66 ml of diethyl sulphate and 170 ml of 10% NaOH solution is refluxed for 2 hours. After cooling the reaction mixture to RT, it is extracted with EtOAc, the organic phase is washed with 2N NaOH solution and dried over Na2SO4, and the solvent is evaporated off under vacuum. 19.6 g of the expected product are obtained.

後処理

  1. temperatureis refluxed for 2 hours
  2. extractionit is extracted with EtOAc
  3. washthe organic phase is washed with 2N NaOH solution
  4. dry with materialdried over Na2SO4
  5. customthe solvent is evaporated off under vacuum

出典と根拠

ORDレコード
ord-7430bb1eac354422a753a5f7420cbe7a
出典データセット
uspto-grants-2008_09
特許番号
US07425566B2

関連ノート

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