反応式
S(Cl)([Cl:3])=O.[I:5][C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][C:14]=1[CH3:15])[C:9](O)=[O:10]>C(Cl)(Cl)Cl>[I:5][C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][C:14]=1[CH3:15])[C:9]([Cl:3])=[O:10]参加物
4
反応条件
- 温度
- 61 °C
実験手順
Thionyl chloride (8.2 ml, 112.5 mmol) was added to a mixture of 3-iodo-4-methylbenzoic acid (18.5 g, 75 mmol) in chloroform (100 ml) and heated at 61° C. for 16 hours. The solvent was removed in vacuo and excess thionyl chloride removed by azeotroping with toluene (3×30 ml). The desired product was formed as a beige solid (19.5 g 93%) and used in subsequent reactions without further purification.
後処理
- customThe solvent was removed in vacuo and excess thionyl chloride
- customremoved
- customby azeotroping with toluene (3×30 ml)
出典と根拠
- ORDレコード
- ord-f706d26ebb73471d909c51f1695ddd4a
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07425555B2
関連ノート
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