Dichloromethane → 4-bromo-N'-(2,2-dimethylpropanoyl)benzohydrazide

HRID 31421

反応式

HRID 31421 の反応式
C(O[C:6]([NH:8][NH2:9])=[O:7])(C)(C)C.[Br:10][C:11]1[CH:19]=[CH:18][C:14]([C:15](Cl)=[O:16])=[CH:13][CH:12]=1.CCN([CH:26]([CH3:28])[CH3:27])C(C)C.[Cl-].[NH4+].[CH2:31](Cl)Cl>>[CH3:27][C:26]([CH3:28])([CH3:31])[C:6]([NH:8][NH:9][C:15](=[O:16])[C:14]1[CH:18]=[CH:19][C:11]([Br:10])=[CH:12][CH:13]=1)=[O:7]

参加物

6

反応物 5

HCID 6344DichloromethaneHCID 25517Ammonium ChlorideHCID 685154-Bromobenzoyl chlorideHCID 70091tert-Butyl carbazateHCID 81531Diisopropylethylamine

生成物 1

HCID 47826934-bromo-N'-(2,2-dimethylpropanoyl)benzohydrazide

実験手順

t-Butyloxycarbonylhydrazine (1.26 g) was added portionwise to a solution of 4-bromobenzoyl chloride (2.0 g), and DIPEA (2.37 ml) in DCM (20 ml) and the reaction stirred at room temperature for 18 hours. Ammonium chloride solution was added, the organic phase was separated, dried and the solvent evaporated under vacuum to give 4-bromo-benzoic acid N′-(2,2-dimethyl-propionyl)-hydrazide.

後処理

  1. customthe organic phase was separated
  2. customdried
  3. customthe solvent evaporated under vacuum

出典と根拠

ORDレコード
ord-8132fc3f3dc447e5b26609efe5f81896
出典データセット
uspto-grants-2008_09
特許番号
US07425555B2

関連ノート

読み込み中…