2-Imidazoline → 1-(4-Ethylphenyl)-2-imidazolylethan-1-one

HRID 31779

反応式

HRID 31779 の反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH3:12])=[CH:7][CH:6]=1)=[O:4].[NH:13]1[CH2:17][CH2:16][N:15]=[CH:14]1>C(#N)C>[CH2:11]([C:8]1[CH:9]=[CH:10][C:5]([C:3](=[O:4])[CH2:2][C:14]2[NH:13][CH:17]=[CH:16][N:15]=2)=[CH:6][CH:7]=1)[CH3:12]

参加物

4

反応物 2

HCID 681562-ImidazolineHCID 124019512-Bromo-1-(4-ethylphenyl)ethan-1-one

生成物 1

HCID 221425781-(4-Ethylphenyl)-2-imidazolylethan-1-one

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒2 回

実験手順

1 mmol of 2-bromo-1-(4-ethylphenyl)ethan-1-one in acetonitrile was added drop wise to 5.5 mmol imidazoline in acetonitrile at room temperature for fourteen hours. The reaction mixture was concentrated in vacuo and diluted with water and ethyl acetate. The solution was extracted three times with ethyl acetate and dried over sodium sulfate to obtain 1-(4-ethylphenyl)-2-imidazolylethan-1-one.

後処理

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. additiondiluted with water and ethyl acetate
  3. extractionThe solution was extracted three times with ethyl acetate
  4. dry with materialdried over sodium sulfate

出典と根拠

ORDレコード
ord-24ee89c2f0684d92a2fe9090065cfceb
出典データセット
uspto-grants-2008_09
特許番号
US07425557B2

関連ノート

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