Dimethylformamide → [4-(2,4-Dichlorophenyl)-5-imidazol-2-ylpyrimidin-2-yl]{2-[(6-methoxy-5-nitro(2-pyridyl)) amino]ethyl}amine

HRID 31820

反応式

HRID 31820 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:14]([C:15]2[NH:16][CH:17]=[CH:18][N:19]=2)=[CH:13][N:12]=[C:11](CCN)[N:10]=1.[CH3:23][O:24][C:25]1[C:30]([N+:31]([O-:33])=[O:32])=[CH:29][CH:28]=[C:27](Cl)[N:26]=1.C([N:38](C(C)C)[CH2:39][CH3:40])(C)C.C[N:45](C=O)C>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:14]([C:15]2[NH:19][CH:18]=[CH:17][N:16]=2)=[CH:13][N:12]=[C:11]([NH:38][CH2:39][CH2:40][NH:45][C:27]2[CH:28]=[CH:29][C:30]([N+:31]([O-:33])=[O:32])=[C:25]([O:24][CH3:23])[N:26]=2)[N:10]=1

参加物

5

反応物 4

HCID 6228DimethylformamideHCID 81531DiisopropylethylamineHCID 107977036-Chloro-2-methoxy-3-nitropyridineHCID 542317734-(2,4-Dichlorophenyl)-5-imidazolylpyrimidin-2-ylethylamine

生成物 1

HCID 22142635[4-(2,4-Dichlorophenyl)-5-imidazol-2-ylpyrimidin-2-yl]{2-[(6-methoxy-5-nitro(2-pyridyl)) amino]ethyl}amine

反応条件

温度
80 °C

実験手順

To a solution of [4-(2,4-dichlorophenyl)-5-imidazol-2-ylpyrimidin-2-ylethylamine (20 mg, 0.04 mmol) in DMF (1 ml), 2-methoxy-3-nitro-6-chloro-pyridine (8.3 mg, 0.04 mmol) and diisopropylethyl amine (31 μl, 0.18 mmol) were added. The reaction mixture was stirred for 12 hours at 80° C. The crude mixture was concentrated in vacuo and subjected to column chromatography (10% methanol in methylene chloride) to afford [4-(2,4-dichlorophenyl)-5-imidazol-2-ylpyrimidin-2-yl]{2-[(6-methoxy-5-nitro(2-pyridyl))-amino]ethyl}amine as bright yellow solid.

後処理

  1. concentrationThe crude mixture was concentrated in vacuo

出典と根拠

ORDレコード
ord-351c0e8e60d64b93b02b64e94b9240be
出典データセット
uspto-grants-2008_09
特許番号
US07425557B2

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