Thionyl Chloride → 4-(Trifluoromethyl)cinnamoyl chloride

HRID 322007

反応式

HRID 322007 の反応式
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:13]=[CH:12][C:6](/[CH:7]=[CH:8]/[C:9](O)=[O:10])=[CH:5][CH:4]=1.S(Cl)([Cl:18])=O>CN(C=O)C>[F:1][C:2]([F:15])([F:14])[C:3]1[CH:13]=[CH:12][C:6](/[CH:7]=[CH:8]/[C:9]([Cl:18])=[O:10])=[CH:5][CH:4]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 6880704-(Trifluoromethyl)cinnamic acid

生成物 1

HCID 111072914-(Trifluoromethyl)cinnamoyl chloride

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide触媒

反応条件

温度
75 °C

実験手順

200.0 mg (0.92 mmol) of trans-4-trifluoromethylcinnamic acid were treated with 200 μl of thionyl chloride. After addition of 2 drops of DMF, the reaction solution obtained was stirred at 75° C. for 3 h. It was then concentrated to dryness, and the residue was taken up in toluene 2× and concentrated to dryness again. Drying in a high vacuum yielded 237.0 mg of the title compound as a slightly yellow, amorphous powder.

後処理

  1. customthe reaction solution obtained
  2. concentrationIt was then concentrated to dryness
  3. concentrationconcentrated to dryness again
  4. customDrying in a high vacuum

出典と根拠

ORDレコード
ord-fc6c1c230be84f99a7c445e3d7914d02
出典データセット
uspto-grants-2001_04
特許番号
US06211196B1

関連ノート

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