Thionyl Chloride → 1-(2-Chloroethoxy)-4-nitrobenzene

HRID 322630

反応式

HRID 322630 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH2:12]O)=[CH:6][CH:5]=1)([O-:3])=[O:2].S(Cl)([Cl:16])=O>>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH2:12][Cl:16])=[CH:6][CH:5]=1)([O-:3])=[O:2]

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 853812-(4-Nitrophenoxy)ethanol

生成物 1

HCID 27645871-(2-Chloroethoxy)-4-nitrobenzene

実験手順

4-Nitro-(2-Hydroxyethoxy)benzene (1.13 g, 6.2 mmol) in thionyl chloride (10 mL) is heated at reflux for 3 hours then concentrated in vacuo. After cooling the residue in an ice water bath, saturated aqueous sodium bicarbonate is added and the precipitate collected, rinsed with water, and dried to give 4-nitro-(2-chloroethoxy)benzene (909 mg).

後処理

  1. temperatureat reflux for 3 hours
  2. concentrationthen concentrated in vacuo
  3. temperatureAfter cooling the residue in an ice water bath
  4. additionsaturated aqueous sodium bicarbonate is added
  5. customthe precipitate collected
  6. washrinsed with water
  7. customdried

出典と根拠

ORDレコード
ord-c4e1a6c1250a445185e50851c001f832
出典データセット
uspto-grants-2001_04
特許番号
US06211365B1

関連ノート

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