Pyridine → 2,4-Dibenzyloxybenzaldehyde oxime

HRID 322858

反応式

HRID 322858 の反応式
[CH2:1]([O:8][C:9]1[CH:16]=[C:15]([O:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:14]=[CH:13][C:10]=1[CH:11]=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[NH2:26][OH:27].N1C=CC=CC=1>C(O)C>[CH2:1]([O:8][C:9]1[CH:16]=[C:15]([O:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:14]=[CH:13][C:10]=1[CH:11]=[N:26][OH:27])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 1049PyridineHCID 443297Hydroxyamine hydrochlorideHCID 18090802,4-Bis(benzyloxy)benzaldehyde

生成物 1

HCID 852413792,4-Dibenzyloxybenzaldehyde oxime

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 2,4-dibenzyloxybenzaldehyde (2 g), hydroxylamine hydrochloride (0.45 g) and pyridine (0.53 mL) in ethanol (20 mL) is heated at reflux for 1 hour. The solvent is then removed in vacuo, the residue dissolved in ethyl acetate and the solution washed with 1 N hydrochloric acid then with brine. Removal of the solvent in vacuo gives a beige coloured solid which crystallises from a mixture of ether and petroleum ether to give 2,4-dibenzyloxybenzaldehyde oxime in the form of a white solid, m.p., 130° C. [Elemental analysis:- C,76.1; H,5.75; N,4.28%. Calculated:- C,75.7; H,5.74; N,4.20%].

後処理

  1. temperatureis heated
  2. temperatureat reflux for 1 hour
  3. customThe solvent is then removed in vacuo
  4. dissolutionthe residue dissolved in ethyl acetate
  5. washthe solution washed with 1 N hydrochloric acid
  6. customRemoval of the solvent in vacuo
  7. customgives a beige coloured solid which
  8. customcrystallises from a mixture of ether and petroleum ether

出典と根拠

ORDレコード
ord-38a57faa9777465d89a5ebd4d11bc548
出典データセット
uspto-grants-2001_04
特許番号
US06211234B1

関連ノート

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