1-Methyluracil → HCID 178432331、化合物

HRID 324472

反応式

HRID 324472 の反応式
[CH3:1][C:2]1[N:3](CC2C=CC(OC)=CC=2)[C:4]2[CH:11]=[CH:10][C:9]3[CH:12]=[CH:13][CH:14]=[CH:15][C:8]=3[CH:7](O)[C:5]=2[N:6]=1.[CH3:26][N:27]1[CH:34]=[CH:33][C:31](=[O:32])[NH:30][C:28]1=[O:29]>FC(F)(F)C(O)=O>[CH3:26][N:27]1[CH:34]=[C:33]([CH:7]2[C:5]3[N:6]=[C:2]([CH3:1])[NH:3][C:4]=3[CH:11]=[CH:10][C:9]3[CH:12]=[CH:13][CH:14]=[CH:15][C:8]2=3)[C:31](=[O:32])[NH:30][C:28]1=[O:29]

参加物

4

反応物 2

HCID 120091-MethyluracilHCID 220036712-Methyl-1-(4-methoxyphenylmethyl)-4H-benzo[5,6]cyclohepta[1,2-d]imidazol-4-ol

生成物 1

HCID 178432331HCID 178432331、化合物

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

A stirred solution of the product from step (iii) (0.819 g) in trifluoroacetic acid (20 ml) was heated at reflux for 1 h. 1-Methyluracil (0.311 g) was added and the reflux continued for 5 days. The solvent was evaporated under reduced pressure. The residue was purified by chromatography eluting with 10% methanol in dichloromethane to give the subtitle product as pale green glass.

後処理

  1. temperatureat reflux for 1 h
  2. customThe solvent was evaporated under reduced pressure
  3. customThe residue was purified by chromatography
  4. washeluting with 10% methanol in dichloromethane

出典と根拠

ORDレコード
ord-a866e5d4415144668ea8de1cb16098af
出典データセット
uspto-grants-2001_04
特許番号
US06218376B1

関連ノート

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