HCID 13020137、化合物 → Aspartame

HRID 325272

反応式

HRID 325272 の反応式
O.O.Cl.[CH3:4][O:5][C:6](=[O:24])[C@H:7]([CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[NH:8][C:9](=[O:16])[C@H:10]([CH2:12][C:13](=[O:15])[OH:14])[NH2:11]>O.C(=O)([O-])[O-].[Na+].[Na+]>[CH3:4][O:5][C:6](=[O:24])[C@H:7]([CH2:17][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)[NH:8][C:9](=[O:16])[C@H:10]([CH2:12][C:13](=[O:14])[OH:15])[NH2:11]

参加物

4

反応物 1

HCID 13020137HCID 13020137、化合物

生成物 1

HCID 134601Aspartame

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 10340Sodium Carbonate溶媒

反応条件

温度
60 °C

実験手順

12.5 parts of α-L-aspartyl-L-phenylalanine methyl ester hydrochloride dihydrate was dissolved in 100 parts by volume of water and aqueous sodium carbonate added to pH3, then heated to 60° C. and adjusted to pH4.6. The reaction mixture was cooled to 5° C. for three hours and the precipitate was collected on a filter and dried for 18 hours under vacuum at 60° C. to give 7.6 parts α-L-aspartyl-L-phenylalanine methyl ester.

後処理

  1. additionadded to pH3
  2. temperatureThe reaction mixture was cooled to 5° C. for three hours
  3. customthe precipitate was collected on
  4. filtrationa filter
  5. customdried for 18 hours under vacuum at 60° C.

出典と根拠

ORDレコード
ord-b52bf4bd30e9450389f6c36bd5e856f1
出典データセット
uspto-grants-1984_04
特許番号
US04440677

関連ノート

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