Hydrochloric Acid → 2-Amino-3-(trifluoromethyl)benzoic acid

HRID 325485

反応式

HRID 325485 の反応式
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:11]=1[NH:10]C(=O)[C:8]2=[O:13].[OH:16]O.Cl>[OH-].[Na+].O>[F:14][C:2]([F:1])([F:15])[C:3]1[C:11]([NH2:10])=[C:7]([CH:6]=[CH:5][CH:4]=1)[C:8]([OH:13])=[O:16]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 784Hydrogen PeroxideHCID 6045757-Trifluoromethylisatin

生成物 1

HCID 6045692-Amino-3-(trifluoromethyl)benzoic acid

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

7-Trifluoromethylisatin (10 g, 46 mmol) was dissolved in 5% sodium hydroxide solution (83 ml). To this was added dropwise over 30 minutes a solution of 50% hydrogen peroxide (7.4 ml) in water (4.6 ml); the temperature rose to 50°. The solution was stirred an additional 30 minutes, acidified (conc. HCl) to pH 1-2, and the tan product was filtered.

後処理

  1. customrose to 50°
  2. filtrationthe tan product was filtered

出典と根拠

ORDレコード
ord-c4d53f54931b4664aa89f8d725f00624
出典データセット
uspto-grants-1984_04
特許番号
US04440941

関連ノート

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