Hydrochloric Acid → 2-Amino-3-(trifluoromethyl)benzoic acid
反応式
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:11]=1[NH:10]C(=O)[C:8]2=[O:13].[OH:16]O.Cl>[OH-].[Na+].O>[F:14][C:2]([F:1])([F:15])[C:3]1[C:11]([NH2:10])=[C:7]([CH:6]=[CH:5][CH:4]=1)[C:8]([OH:13])=[O:16]参加物
6
実験手順
7-Trifluoromethylisatin (10 g, 46 mmol) was dissolved in 5% sodium hydroxide solution (83 ml). To this was added dropwise over 30 minutes a solution of 50% hydrogen peroxide (7.4 ml) in water (4.6 ml); the temperature rose to 50°. The solution was stirred an additional 30 minutes, acidified (conc. HCl) to pH 1-2, and the tan product was filtered.
後処理
- customrose to 50°
- filtrationthe tan product was filtered
出典と根拠
- ORDレコード
- ord-c4d53f54931b4664aa89f8d725f00624
- 出典データセット
- uspto-grants-1984_04
- 特許番号
- US04440941
反応ノート
読み込み中…