Sodium Hydroxide → Enoxacin

HRID 325612

反応式

HRID 325612 の反応式
[CH3:1][CH2:2][N:3]1[C:9]2[N:10]=[C:11]([N:15]3[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)[C:12]([F:14])=[CH:13][C:8]=2[C:6](=[O:7])[C:5]([C:21]([OH:23])=[O:22])=[CH:4]1.Cl.[OH-].[Na+]>O>[CH3:1][CH2:2][N:3]1[C:9]2[N:10]=[C:11]([N:15]3[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]3)[C:12]([F:14])=[CH:13][C:8]=2[C:6](=[O:7])[C:5]([C:21]([OH:23])=[O:22])=[CH:4]1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 12901163Enoxacin hydrochloride

生成物 1

HCID 3229Enoxacin

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
70 °C

実験手順

About 10 g of AT-2266.hydrochloride was dissolved to hot water (about 70° C.) and the solution was neutralized with 15% aqueous solution of sodium hydroxide which was warmed to 70° C. previously. The precipitate was collected by filtration and dried at 70° to 80° C. for elimination of adhering water to give the AT-2266.sesquihydrate.

後処理

  1. filtrationThe precipitate was collected by filtration
  2. dry with materialdried at 70° to 80° C. for elimination of adhering water

出典と根拠

ORDレコード
ord-b477c5e573b74f0f821d8fb612284fb3
出典データセット
uspto-grants-1984_04
特許番号
US04442101

関連ノート

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