Sodium Hydroxide → Pentiapine

HRID 326056

反応式

HRID 326056 の反応式
[C:1]([N:6]1[CH2:11][CH2:10][N:9]([C:12]2[N:13]3[CH:25]=[CH:24][N:23]=[C:14]3[S:15][C:16]3[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=3[N:18]=2)[CH2:8][CH2:7]1)(OCC)=O.[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[Na+]>O1CCCC1>[CH3:1][N:6]1[CH2:11][CH2:10][N:9]([C:12]2[N:13]3[CH:25]=[CH:24][N:23]=[C:14]3[S:15][C:16]3[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=3[N:18]=2)[CH2:8][CH2:7]1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 131782745-(4-Carboethoxypiperazino)-imidazo[2,1-b][1,3,5]benzothiadiazepineHCID 21226445Aluminium lithium hydride

生成物 1

HCID 54742Pentiapine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To the solution of 0.2 g of 5-(4-carboethoxypiperazino)-imidazo[2,1-b][1,3,5]benzothiadiazepine in 2 ml of dry tetrahydrofuran, 100 mg of lithium aluminum hydride are added at once and the mixture is refluxed under nitrogen for 48 hrs. The mixture is cooled to room temperature, stirred with 0.2 ml of 30% sodium hydroxide, and filtered. The filtrates were evaporated to dryness and the product is purified to give 5-(4-methylpiperazino)-imidazo[2,1-b][1,3,5]benzothiadiazepine, melting at 145°-7°, and identical to compound obtained in example 1.

後処理

  1. temperatureis refluxed under nitrogen for 48 hrs
  2. filtrationfiltered
  3. customThe filtrates were evaporated to dryness
  4. customthe product is purified

出典と根拠

ORDレコード
ord-e5445d6f87eb4eac86c58649f7cd142f
出典データセット
uspto-grants-1984_04
特許番号
US04444688

関連ノート

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