Water → 4-{[5-(7-Amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-4-phenyl-1H-imidazol-1-yl]methyl}cyclohexanone

HRID 32629ノート

反応式

HRID 32629 の反応式
O1[C:5]2([CH2:10][CH2:9][CH:8]([CH2:11][N:12]3[C:16]([C:17]4[S:18][C:19]5[N:20]=[CH:21][N:22]=[C:23]([NH2:26])[C:24]=5[N:25]=4)=[C:15]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)[N:14]=[CH:13]3)[CH2:7][CH2:6]2)[O:4]CC1.O.C(O)(C(F)(F)F)=O>CC#N>[NH2:26][C:23]1[C:24]2[N:25]=[C:17]([C:16]3[N:12]([CH2:11][CH:8]4[CH2:9][CH2:10][C:5](=[O:4])[CH2:6][CH2:7]4)[CH:13]=[N:14][C:15]=3[C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)[S:18][C:19]=2[N:20]=[CH:21][N:22]=1

参加物

5

反応物 3

HCID 962WaterHCID 6422Trifluoroacetic acidHCID 10095197HCID 10095197、化合物

生成物 1

HCID 100012704-{[5-(7-Amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-4-phenyl-1H-imidazol-1-yl]methyl}cyclohexanone

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

2-[1-(1,4-Dioxaspiro[4,5]dec-8-ylmethyl)-4-phenyl-1H-imidazol-5-yl][1,3]thiazolo[5,4-d]pyrimidin-7-amine (Example 178) (634 mg) was dissolved in MeCN (10 mL) and water (10 mL) and TFA (0.5 mL) was added. After 48 hours at ambient temperature, the title compound was obtained by preparative RPHPLC (eluting with a gradient of water and MeCN containing 0.1% TFA) as a colourless solid (570 mg, 99%);

出典と根拠

ORDレコード
ord-3e7f4097845d4d9b8b6e0fd3192ac110
出典データセット
uspto-grants-2008_09
特許番号
US07427616B2

反応ノート

読み込み中…