Benzyl Chloride → Benzyl 4-methyl-2-oxopentanoate

HRID 326377

反応式

HRID 326377 の反応式
[Na+].[O:2]=[C:3]([CH2:7][CH:8]([CH3:10])[CH3:9])[C:4]([O-:6])=[O:5].[CH2:11](Cl)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>CN(C=O)C.C(Cl)(Cl)Cl>[CH3:9][CH:8]([CH3:10])[CH2:7][C:3](=[O:2])[C:4]([O:6][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:5]

参加物

5

反応物 2

HCID 7503Benzyl ChlorideHCID 4137900Sodium 4-methyl-2-oxovalerate

生成物 1

HCID 4072499Benzyl 4-methyl-2-oxopentanoate収率 94%

試薬・触媒・溶媒 2

HCID 6212Chloroform溶媒HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 2-Oxo-4-methyl pentanoic acid sodium salt (10 g, 65.7 mmol) and benzyl chloride (8 g, 63 mmol) in 300 ml DMF was stirred at 40°-50° C. for 5 h. It was filtered, and the filtrate was evaporated under reduced pressure to provide an oil. The oil was dissolved in chloroform, washed with water, dried, filtered, and evaporated to provide the desired product (13 g, 94%). 1H NMR (CDCl3, TMS) δ0.95 (d,6H), 2.15 (m,1H), 2.7 (d,2H), 5.28 (s,2H), 7.4 (m,5H). Mass spectrum: (M+H)+ =221.

後処理

  1. filtrationIt was filtered
  2. customthe filtrate was evaporated under reduced pressure
  3. customto provide an oil
  4. washwashed with water
  5. customdried
  6. filtrationfiltered
  7. customevaporated

出典と根拠

ORDレコード
ord-17556ae88132457880ffb3476e669674
出典データセット
uspto-grants-1993_12
特許番号
US05268374

関連ノート

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