Carbamic acid, ethyl ester → 5-Stearyloxymethyl-2-oxazolidinone

HRID 326405

反応式

[C:1](=[O:6])([O:3][CH2:4][CH3:5])[NH2:2].C([O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])C1OC1.[CH3:30]N(CC1C=CC=CC=1)C>C([O-])(=O)CCCCCCCCCCC.C([O-])(=O)CCCCCCCCCCC.C([Sn+2]CCCC)CCC>[CH2:12]([O:11][CH2:5][CH:4]1[O:3][C:1](=[O:6])[NH:2][CH2:30]1)[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29]

参加物

反応条件

温度: 160 °C

実験手順

4.45 g (0.050 mole) of ethyl carbamate was dissolved in 16.3 g (0.050 mole) of stearyl glycidyl ether. After adding 2.0 g of N, N-dimethylbenzylamine and 2.0 g of di-n-butyltin dilaurate, the solution was heated at 160° C. for 1 hour while blowing nitrogen gas into the reaction mixture. The product was purified by silica gel column chromatography (developing solvent, hexane: ethyl acetate=4:1) to give 15.9 g (85% of theory) of 5-stearyloxymethyl-2- oxazolidinone.

後処理

customThe product was purified by silica gel column chromatography (developing solvent, hexane: ethyl acetate=4:1)

出典と根拠

ORDレコード: ord-5e4d94a8c621480da7a0c4d4efebc675
出典データセット: uspto-grants-1993_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05268484

反応式

参加物

反応物 3

生成物 1

試薬・触媒・溶媒 1

反応条件

実験手順

後処理

出典と根拠

関連ノート