Benzoic Acid → 2-Chloro-5-cyclopropylmethanesulfonyl-benzoic acid

HRID 32668

反応式

HRID 32668 の反応式
C(O)(=O)[C:2]1[CH:7]=[CH:6][CH:5]=CC=1.[Cl:10][C:11]1[CH:19]=[CH:18][C:17]([S:20]([OH:22])=[O:21])=[CH:16][C:12]=1[C:13]([OH:15])=[O:14].BrCC1CC1.II>C1(CO)CC1>[Cl:10][C:11]1[CH:19]=[CH:18][C:17]([S:20]([CH2:5][CH:6]2[CH2:2][CH2:7]2)(=[O:22])=[O:21])=[CH:16][C:12]=1[C:13]([OH:15])=[O:14]

参加物

6

反応物 4

HCID 243Benzoic AcidHCID 807IodineHCID 81503BromomethylcyclopropaneHCID 151129042-Chloro-5-sulfino-benzoic acid

生成物 1

HCID 435605642-Chloro-5-cyclopropylmethanesulfonyl-benzoic acid収率 8%

試薬・触媒・溶媒 1

HCID 75644Cyclopropanemethanol溶媒

実験手順

The title compound was synthesised according to the procedure described for the synthesis of 2-Chloro-5-methanesulfonyl)-benzoic acid from 2-Chloro-5-sulfino-benzoic acid and Bromomethyl-cyclopropane (+catalytic amount I2) in 20 ml cyclopropyl methanol/20 ml water and obtained in 8% yield. MS (m/e): 273.1 (MH−, 100%).

後処理

  1. customobtained in 8% yield

出典と根拠

ORDレコード
ord-6074aae533fb4a4fa4fccb4f830f50df
出典データセット
uspto-grants-2008_09
特許番号
US07427612B2

関連ノート

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