Pyrrolidine → 5-(Cyclopropylmethyl-sulfamoyl)-2-pyrrolidin-1-yl-benzoic acid

HRID 32683

反応式

HRID 32683 の反応式
C[S:2]([C:5]1[CH:6]=[CH:7][C:8]([N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)=[C:9]([CH:13]=1)[C:10]([OH:12])=[O:11])(=[O:4])=[O:3].ClC1C=CC(S(=O)(=O)[NH:30][CH2:31][CH:32]2[CH2:34][CH2:33]2)=CC=1C(O)=O.N1CCCC1>>[CH:32]1([CH2:31][NH:30][S:2]([C:5]2[CH:6]=[CH:7][C:8]([N:14]3[CH2:18][CH2:17][CH2:16][CH2:15]3)=[C:9]([CH:13]=2)[C:10]([OH:12])=[O:11])(=[O:4])=[O:3])[CH2:34][CH2:33]1

参加物

4

反応物 3

HCID 31268PyrrolidineHCID 290355802-Chloro-5-(cyclopropylmethyl-sulfamoyl)-benzoic acidHCID 597934895-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid

生成物 1

HCID 597934955-(Cyclopropylmethyl-sulfamoyl)-2-pyrrolidin-1-yl-benzoic acid収率 38%

実験手順

The title compound was synthesised according to the procedure described for the synthesis of 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid from 2-Chloro-5-(cyclopropylmethyl-sulfamoyl)-benzoic acid and pyrrolidine and obtained in 38% yield. MS (m/e): 323.2 (MH−, 100%).

後処理

  1. customobtained in 38% yield

出典と根拠

ORDレコード
ord-04a9c757ff6849db868de1d25524796e
出典データセット
uspto-grants-2008_09
特許番号
US07427612B2

関連ノート

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