Dicyclohexylcarbodiimide → Maleimidoacetic acid N-hydroxysuccinimide ester
反応式
[C:1]1(=[O:11])[N:5]([CH2:6][C:7]([OH:9])=[O:8])[C:4](=[O:10])[CH:3]=[CH:2]1.O[N:13]1[C:17](=[O:18])[CH2:16][CH2:15][C:14]1=[O:19].C1(N=C=NC2CCCCC2)CCCCC1>COCCOCCOC>[CH2:16]1[C:17](=[O:18])[N:13]([O:8][C:7]([CH2:6][N:5]2[C:4](=[O:10])[CH:3]=[CH:2][C:1]2=[O:11])=[O:9])[C:14](=[O:19])[CH2:15]1参加物
5
実験手順
Maleimidoacetic acid (155 mg, 1.0 mmol) in 5 ml of diglyme was treated at 0° C. with N-hydroxysuccinimide (127 mg, 1.1 mmol) and dicyclohexylcarbodiimide (227 mg, 1.1 mmol). After 1 hour at 0° C. and 3 hours at room temperature, the reaction mixture was filtered and evaporated to dryness to yield 0.25 g of crude maleimidoacetic acid N-succinimidyl ester.
後処理
- filtration3 hours at room temperature, the reaction mixture was filtered
- customevaporated to dryness
出典と根拠
- ORDレコード
- ord-af1dc5f34405494aaf454788d0f1a090
- 出典データセット
- uspto-grants-1993_12
- 特許番号
- US05273743
反応ノート
読み込み中…