Oxalyl chloride → 1-Methyl-4-nitro-1H-imidazole-2-carbonyl chloride

HRID 327423ノート

反応式

HRID 327423 の反応式
[CH3:1][N:2]1[CH:6]=[C:5]([N+:7]([O-:9])=[O:8])[N:4]=[C:3]1[C:10]([OH:12])=O.C(Cl)(=O)C([Cl:16])=O>C1COCC1>[CH3:1][N:2]1[CH:6]=[C:5]([N+:7]([O-:9])=[O:8])[N:4]=[C:3]1[C:10]([Cl:16])=[O:12]

参加物

4

反応物 2

HCID 65578Oxalyl chlorideHCID 120679981-Methyl-4-nitro-1H-imidazole-2-carboxylic acid

生成物 1

HCID 191086291-Methyl-4-nitro-1H-imidazole-2-carbonyl chloride

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 1-methyl-4-nitroimidazole-2-carboxylic acid (2.0 g, 0.012 mol) in dry THF (20 mL) was slowly added oxalyl chloride (6 mL). The solution was heated to reflux for 45 minutes, and the solvent and excess oxalyl chloride were removed under reduced pressure to give 1-methyl-4-nitroimidazole-2-carbonyl chloride as a yellow powder which was coevaporated with dry CH2Cl2 (15 mL).

後処理

  1. temperatureThe solution was heated
  2. temperatureto reflux for 45 minutes
  3. customthe solvent and excess oxalyl chloride were removed under reduced pressure

出典と根拠

ORDレコード
ord-d05f0e15c49f4f5eaa690a306ce1426a
出典データセット
uspto-grants-1993_12
特許番号
US05273991

反応ノート

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