Oxalyl chloride → 1-Methyl-4-nitro-1H-imidazole-2-carbonyl chloride

HRID 327427ノート

反応式

HRID 327427 の反応式
[CH3:1][N:2]1[CH:6]=[C:5]([N+:7]([O-:9])=[O:8])[N:4]=[C:3]1[C:10]([OH:12])=O.C(Cl)(=O)C([Cl:16])=O>C1COCC1>[CH3:1][N:2]1[CH:6]=[C:5]([N+:7]([O-:9])=[O:8])[N:4]=[C:3]1[C:10]([Cl:16])=[O:12]

参加物

4

反応物 2

HCID 65578Oxalyl chloride2 回HCID 120679981-Methyl-4-nitro-1H-imidazole-2-carboxylic acid

生成物 1

HCID 191086291-Methyl-4-nitro-1H-imidazole-2-carbonyl chloride

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To a suspension of 1-methyl-4-nitroimidazole-2-carboxylic acid (3.00 g, 17.5 mmol) in dry THF (30 mL) was slowly added oxalyl chloride (12 mL). The reaction mixture was heated to reflux under a drying tube for 45 minutes at which time the excess oxalyl chloride and THF were removed under reduced pressure and the acid chloride coevaporated twice with dry CH2Cl2 (20 mL each) yielding 1-methyl-4-nitroimidazole-2-carbonyl chloride as a yellow powder.

後処理

  1. temperatureThe reaction mixture was heated
  2. customwere removed under reduced pressure

出典と根拠

ORDレコード
ord-c4c400ae5f8048268425aac0e1979e00
出典データセット
uspto-grants-1993_12
特許番号
US05273991

反応ノート

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