Hydrochloric Acid → 3,4,5-Trimethoxyphenylacetic acid

HRID 327499

反応式

HRID 327499 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:13][C:14]#N)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[OH-:16].[Na+].Cl.C[OH:20].O>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:13][C:14]([OH:20])=[O:16])[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10]

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 258873,4,5-Trimethoxyphenylacetonitrile2 回HCID 22242641Methanol--water (1/1)

生成物 1

HCID 703723,4,5-Trimethoxyphenylacetic acid

実験手順

3,4,5-trimethoxyphenyl acetonitrile 5.5 g was dissolved into 50 ml of methanol/water (9:1). To this 1 .5 g of sodium hydroxide was added and they were then stirred and refluxed for 5.5 hours. The temperature of the reactive liquid was lowered down to room temperature and neutralized with 2N hydrochloric acid, and the methanol was distilled off under reduced pressure. Extraction was performed thrice by means of 100 ml of chloroform. After distilling off the solvent under reduced pressure, 5.8 g of captioned compound was obtained.

後処理

  1. temperaturerefluxed for 5.5 hours
  2. distillationthe methanol was distilled off under reduced pressure
  3. extractionExtraction
  4. distillationAfter distilling off the solvent under reduced pressure

出典と根拠

ORDレコード
ord-e7187962b89b4a35b63770f24bc46a23
出典データセット
uspto-grants-1993_12
特許番号
US05273985

関連ノート

読み込み中…