反応式
C[O:2][C:3](=O)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][C:11]([NH:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16](/[CH:20]=[CH:21]/[C:22]2[S:23][CH:24]=[C:25]([CH:27]3[CH2:30][CH2:29][CH2:28]3)[N:26]=2)[CH:15]=1)=[O:12].[BH4-].[Na+].O1CCCC1.CO>O>[CH:27]1([C:25]2[N:26]=[C:22](/[CH:21]=[CH:20]/[C:16]3[CH:15]=[C:14]([NH:13][C:11](=[O:12])[CH2:10][C:5]4[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=4[CH2:3][OH:2])[CH:19]=[CH:18][CH:17]=3)[S:23][CH:24]=2)[CH2:28][CH2:29][CH2:30]1参加物
6
反応物 4
生成物 1
試薬・触媒・溶媒 1
実験手順
A mixture of 0.865 g of (E)-2-[2-[3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid methyl ester, 0.5 g of sodium borohydride, 75 ml of tetrahydrofuran and 20 ml of methanol was stirred under a positive nitrogen atmosphere for 20 hr. The reaction mixture was condensed in vacuo and the residual materials were mixed with water and extracted with methylene chloride. The combined extracts were washed with water, dried (MgSO4) and condensed in vacuo. The residual materials were further purified by chromatography over florisil using ethyl acetate as the eluant to yield (E)-2-[2-[3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzyl alcohol.
後処理
- customcondensed in vacuo
- extractionextracted with methylene chloride
- washThe combined extracts were washed with water
- customdried
- custom(MgSO4) and condensed in vacuo
- customThe residual materials were further purified by chromatography over florisil
出典と根拠
- ORDレコード
- ord-c641292635e94c148bac6e02a8b17cb3
- 出典データセット
- uspto-grants-1993_12
- 特許番号
- US05273986
関連ノート
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