Chloroacetyl chloride → N-benzyl-N-tert-butyl-2-chloroacetamide

HRID 328626

反応式

HRID 328626 の反応式
[CH2:1]([NH:8][C:9]([CH3:12])([CH3:11])[CH3:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+].[Cl:15][CH2:16][C:17](Cl)=[O:18]>ClCCCl>[CH2:1]([N:8]([C:9]([CH3:12])([CH3:11])[CH3:10])[C:17](=[O:18])[CH2:16][Cl:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 6577Chloroacetyl chlorideHCID 14798Sodium HydroxideHCID 76908N-(1,1-Dimethylethyl)benzenemethanamine

生成物 1

HCID 2386050N-benzyl-N-tert-butyl-2-chloroacetamide

試薬・触媒・溶媒 1

HCID 111,2-Dichloroethane溶媒

実験手順

To a stirred and cooled mixture of 33 parts of N-benzyl-N-tert.-butylamine in 60 parts of sodium hydroxide solution 20% and 160 parts of 1,2-dichloroethane are added dropwise 34 parts of 2-chloroacetyl chloride at a temperature between -5° and -10° C. Upon completion, stirring is continued at the same temperature for one hour. The reaction mixture is allowed to reach room temperature and the organic layer is separated, washed with water, dried and evaporated, yielding 43 parts of N-benzyl-N-tert.-butyl-2-chloroacetamide as a residue.

後処理

  1. temperaturecooled
  2. stirringUpon completion, stirring
  3. customto reach room temperature
  4. customthe organic layer is separated
  5. washwashed with water
  6. customdried
  7. customevaporated

出典と根拠

ORDレコード
ord-5f90d87b76b841d88b04a4c41097ad9d
出典データセット
uspto-grants-1977_04
特許番号
US04017631

関連ノート

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