1,3-Dibromopropane → HCID 21443206、化合物

HRID 328630ノート

反応式

HRID 328630 の反応式
[CH2:1]([C:4]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:5]=1[OH:11])[CH:2]=[CH2:3].[Br:12][CH2:13][CH2:14][CH2:15]Br.[OH-].[Na+]>O>[CH2:1]([C:4]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:5]=1[O:11][CH2:15][CH2:14][CH2:13][Br:12])[CH:2]=[CH2:3]

参加物

5

反応物 3

HCID 80011,3-DibromopropaneHCID 14798Sodium HydroxideHCID 113441122-Allyl-4-fluorophenol

生成物 1

HCID 21443206HCID 21443206、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

To a stirred and refluxing mixture of 162 parts of 2-allyl-4-fluorophenol, 363 parts of 1,3-dibromopropane in 700 parts of water is added dropwise a solution of 56 parts of sodium hydroxide in 175 parts of water. Upon completion, the whole is stirred and refluxed for 8 hours. After cooling, the aqueous layer is separated and extracted with chloroform. The extract is dried over magnesium sulfate, filtered and evaporated. The oily residue is distilled twice, yielding 142 parts of 3-allyl-4-(3-bromopropoxy)fluorobenzene; bp. 160° -170° C. at 14 mm. pressure.

後処理

  1. temperaturerefluxing
  2. stirringUpon completion, the whole is stirred
  3. temperaturerefluxed for 8 hours
  4. temperatureAfter cooling
  5. customthe aqueous layer is separated
  6. extractionextracted with chloroform
  7. dry with materialThe extract is dried over magnesium sulfate
  8. filtrationfiltered
  9. customevaporated
  10. distillationThe oily residue is distilled twice

出典と根拠

ORDレコード
ord-87b3195e6c63404d8f64072d7ea9afb9
出典データセット
uspto-grants-1977_04
特許番号
US04017631

反応ノート

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