Sodium Hydroxide → 1-(p-Phenoxyphenoxy)-3-(iso-propylamino)-2-propanol

HRID 328889

反応式

HRID 328889 の反応式
[CH:1]([N:4]1[CH2:7][CH:6]([OH:8])[CH2:5]1)([CH3:3])[CH3:2].[O:9]([C:16]1(O)[CH:21]=[CH:20][CH:19]=[CH:18][CH2:17]1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[OH-:23].[Na+]>>[O:9]([C:16]1[CH:21]=[CH:20][C:19]([O:23][CH2:5][CH:6]([OH:8])[CH2:7][NH:4][CH:1]([CH3:2])[CH3:3])=[CH:18][CH:17]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

参加物

4

反応物 3

HCID 14798Sodium HydroxideHCID 5446771-(Propan-2-yl)azetidin-3-olHCID 205173521-Phenoxyphenol

生成物 1

HCID 205173151-(p-Phenoxyphenoxy)-3-(iso-propylamino)-2-propanol収率 58%

反応条件

温度
160 °C

実験手順

To a mixture of 5.8 parts of 1-(iso-propyl)-3-azetidinol and 9.3 parts of 1-phenoxyphenol 0.1 part of sodium hydroxide was added, and the mixture was heated under nitrogen gas at 160° C. for 18 hours. The reaction mixture was cooled and extracted with ether. The extract was washed in water and then the solvent was distilled off. Recrystallization of the residue gave 16.1 parts of 1-(p-phenoxyphenoxy)-3-(iso-propylamino)-2-propanol having a melting point of 72°-74° C. The yield was 58%.

後処理

  1. additionwas added
  2. temperatureThe reaction mixture was cooled
  3. extractionextracted with ether
  4. washThe extract was washed in water
  5. distillationthe solvent was distilled off
  6. customRecrystallization of the residue

出典と根拠

ORDレコード
ord-439dc4399852448982e7db8374c60e24
出典データセット
uspto-grants-1977_04
特許番号
US04018824

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