4-Methyl-5-(2-hydroxyethyl)thiazole → 3-Benzyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride
反応式
[OH:1][CH2:2][CH2:3][C:4]1[S:8][CH:7]=[N:6][C:5]=1[CH3:9].[CH2:10]([Cl:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C(#N)C>[Cl-:17].[CH2:10]([N+:6]1[C:5]([CH3:9])=[C:4]([CH2:3][CH2:2][OH:1])[S:8][CH:7]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1参加物
4
実験手順
71.6 g (500 millimoles) of 5-(2-hydroxyethyl)-4-methyl-1,3-thiazole), 63.3 g (500 millimoles) of freshly distilled benzyl chloride and 250 ml of absolute acetonitrile are refluxed for 24 hours in a 500 ml round-bottomed flask. The stirred reaction mixture is slowly cooled to room temperature, and the precipitate is filtered off under suction, washed colorless with dry acetonitrile, predried and then dried at 90° C. under reduced pressure from a water pump.
後処理
- customThe stirred reaction mixture
- filtrationthe precipitate is filtered off under suction
- washwashed colorless with dry acetonitrile
- dry with materialdried at 90° C. under reduced pressure from a water pump
出典と根拠
- ORDレコード
- ord-a5abeb64212d43c2b640956bcae921cb
- 出典データセット
- uspto-grants-1990_01
- 特許番号
- US04894483
反応ノート
読み込み中…