4-Methyl-5-(2-hydroxyethyl)thiazole → 3-Benzyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride

HRID 330107

反応式

HRID 330107 の反応式
[OH:1][CH2:2][CH2:3][C:4]1[S:8][CH:7]=[N:6][C:5]=1[CH3:9].[CH2:10]([Cl:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C(#N)C>[Cl-:17].[CH2:10]([N+:6]1[C:5]([CH3:9])=[C:4]([CH2:3][CH2:2][OH:1])[S:8][CH:7]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

参加物

4

反応物 2

HCID 11364-Methyl-5-(2-hydroxyethyl)thiazoleHCID 7503Benzyl Chloride

生成物 1

HCID 28333523-Benzyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

71.6 g (500 millimoles) of 5-(2-hydroxyethyl)-4-methyl-1,3-thiazole), 63.3 g (500 millimoles) of freshly distilled benzyl chloride and 250 ml of absolute acetonitrile are refluxed for 24 hours in a 500 ml round-bottomed flask. The stirred reaction mixture is slowly cooled to room temperature, and the precipitate is filtered off under suction, washed colorless with dry acetonitrile, predried and then dried at 90° C. under reduced pressure from a water pump.

後処理

  1. customThe stirred reaction mixture
  2. filtrationthe precipitate is filtered off under suction
  3. washwashed colorless with dry acetonitrile
  4. dry with materialdried at 90° C. under reduced pressure from a water pump

出典と根拠

ORDレコード
ord-a5abeb64212d43c2b640956bcae921cb
出典データセット
uspto-grants-1990_01
特許番号
US04894483

関連ノート

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