Thionyl Chloride → HCID 19869706、化合物

HRID 330305ノート

反応式

HRID 330305 の反応式
[CH2:1]([O:4][C:5]1[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH2:7]O)[CH2:2][CH3:3].S(Cl)([Cl:15])=O>C1(C)C=CC=CC=1.N1C=CC=CC=1>[CH2:1]([O:4][C:5]1[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH2:7][Cl:15])[CH2:2][CH3:3]

参加物

5

反応物 2

HCID 24386Thionyl Chloride2 回HCID 12194601(2-PROPOXYPHENYL)METHANOL

生成物 1

HCID 19869706HCID 19869706、化合物収率 104.6%

試薬・触媒・溶媒 2

HCID 1049Pyridine触媒HCID 1140Toluene溶媒2 回

実験手順

A 2 liter flask was charged with 316 grams (1.9 moles, 1.0 eg.) of 2-propoxybenzyl alcohol and 15 grams of pyridine (0.0126 moles) in 750 ml of toluene. 237 grams (1.99 moles, 1.01 ec.) of thionyl chloride was slowly added dropwise, allowing the reaction mixture to reflux during the addition. The reaction was stirred 4 hours at room temperature after which the toluene and thionyl chloride were removed under reduced pressure. To the remaining oil was added water and ether and washed with saturated NaHCO3 Drying and removal of the solvent gave 367 grams (100% yield) of a red oil.

後処理

  1. temperatureto reflux during the addition
  2. customwere removed under reduced pressure
  3. additionTo the remaining oil was added water and ether
  4. washwashed with saturated NaHCO3 Drying and removal of the solvent

出典と根拠

ORDレコード
ord-1887c46c178047f4904870d84746ad48
出典データセット
uspto-grants-1990_01
特許番号
US04895865

反応ノート

読み込み中…