Cyanuric chloride → 2-Chloro-4,6-bis[(oxiran-2-yl)methoxy]-1,3,5-triazine

HRID 330348ノート

反応式

HRID 330348 の反応式
[N:1]1[C:8](Cl)=[N:7][C:5](Cl)=[N:4][C:2]=1[Cl:3].[O:10]1[CH2:14][CH:11]1[CH2:12][OH:13].[OH-:15].[Na+]>C(Cl)(Cl)Cl>[Cl:3][C:2]1[N:4]=[C:5]([O:13][CH2:12][CH:11]2[O:10][CH2:14]2)[N:7]=[C:8]([O:15][CH2:12][CH:11]2[O:10][CH2:14]2)[N:1]=1

参加物

5

反応物 3

HCID 7954Cyanuric chlorideHCID 11164GlycidolHCID 14798Sodium Hydroxide

生成物 1

HCID 187799312-Chloro-4,6-bis[(oxiran-2-yl)methoxy]-1,3,5-triazine

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

To a mechanically stirred solution of 220.8 g (1.2 mol) cyanuric chloride in 1500 ml chloroform, cooled to 0°-10° C., was added 266.4 g (3.6 mol) 2,3-epoxy-1-propanol in one portion. Aqueous sodium hydroxide (50% solution; 192 g) was added to the mixture dropwise with stirring over about 3 hr maintaining the reaction temperature below 10° C. and preferably around 0°-5° C. The reaction mixture was allowed to warm slowly to room temperature. The chloroform layer was washed with distilled water until neutral and dried over magnesium sulfate. The reaction product was found by nuclear magnetic resonance to be 2-chloro-4,6-diglycidoxy-1,3,5-triazine. Analysis showed about 95% (by weight) chlorodiglycidoxytriazine. The reaction mixture also was found to contain small amounts of triglycidoxytriazine and dichloro monoglycidoxytriazine.

後処理

  1. temperaturemaintaining the reaction temperature below 10° C. and preferably around 0°-5° C
  2. washThe chloroform layer was washed with distilled water until neutral and
  3. dry with materialdried over magnesium sulfate

出典と根拠

ORDレコード
ord-082ba3701cbf478cab5efa205c7b6b08
出典データセット
uspto-grants-1990_01
特許番号
US04895945

反応ノート

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