Tetrahydrofuran → 1-[(4-Methoxyphenyl)diphenylmethoxy]-3-[4-(phenylmethoxy)-phenoxy]-2-propanol

HRID 330499ノート

反応式

HRID 330499 の反応式
[C:1]1([CH2:7][O:8][C:9]2[CH:20]=[CH:19][C:12]([O:13][CH2:14][CH:15]([OH:18])[CH2:16][OH:17])=[CH:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CO[C:23]1[CH:42]=[CH:41][CH:40]=[CH:39][C:24]=1[C:25](Cl)([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1.[O:43]1CCC[CH2:44]1>N1C=CC=CC=1>[CH3:44][O:43][C:29]1[CH:30]=[CH:31][C:26]([C:25]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)([C:24]2[CH:23]=[CH:42][CH:41]=[CH:40][CH:39]=2)[O:17][CH2:16][CH:15]([OH:18])[CH2:14][O:13][C:12]2[CH:19]=[CH:20][C:9]([O:8][CH2:7][C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)=[CH:10][CH:11]=2)=[CH:27][CH:28]=1

参加物

5

反応物 3

HCID 8028TetrahydrofuranHCID 2310801,2-Propanediol, 3-((p-benzyloxy)phenoxy)-HCID 14429619Methoxytrityl chloride

生成物 1

HCID 198685871-[(4-Methoxyphenyl)diphenylmethoxy]-3-[4-(phenylmethoxy)-phenoxy]-2-propanol

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

To a solution of 18.9 g of 3-[4-(phenylmethoxy)-phenoxy]-1,2-propanediol in 50 ml of pyridine and 24 ml of tetrahydrofuran was added 25.57 g of methoxy trityl chloride in several portions. This mixture was stirred for 24 hours and the solvents removed under reduced pressure. The residue was dissolved in chloroform, washed with aqueous sodium bicarbonate, then water, dried and evaporated, giving 30 g of the desired compound.

後処理

  1. customthe solvents removed under reduced pressure
  2. dissolutionThe residue was dissolved in chloroform
  3. washwashed with aqueous sodium bicarbonate
  4. dry with materialwater, dried
  5. customevaporated

出典と根拠

ORDレコード
ord-1409718e0e304a42b5bf18c039401dbd
出典データセット
uspto-grants-1990_01
特許番号
US04897385

反応ノート

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