Magnesium chloride hexahydrate → Vildagliptin Magnesium(II)-Chloride

HRID 332076

反応式

HRID 332076 の反応式
O.O.O.O.O.O.[Cl-:7].[Mg+2:8].[Cl-].[CH2:10]1[CH2:14][N:13]([C:15]([CH2:17][NH:18][C:19]23[CH2:28][C:26]4([OH:29])[CH2:27][CH:21]([CH2:22][CH:23]([CH2:25]4)[CH2:24]2)[CH2:20]3)=[O:16])[C@H:12]([C:30]#[N:31])[CH2:11]1>CC(O)C>[CH2:10]1[CH2:14][N:13]([C:15]([CH2:17][NH:18][C:19]23[CH2:28][C:26]4([OH:29])[CH2:25][CH:23]([CH2:22][CH:21]([CH2:27]4)[CH2:20]2)[CH2:24]3)=[O:16])[C@H:12]([C:30]#[N:31])[CH2:11]1.[Cl-:7].[Mg+2:8].[Cl-:7]

参加物

4

反応物 2

HCID 24644Magnesium chloride hexahydrateHCID 6918537Vildagliptin

生成物 1

HCID 86675510Vildagliptin Magnesium(II)-Chloride

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

0.34 g (1.65 mmole) of magnesium(II)-chloride hexahydrate is dissolved in 15 cm3 of 2-propanol at 50° C. under intensive stirring, and 1.0 g (3.3 mmole) of vildagliptin base is added to the solution. The solution is stirred at room temperature for 2 hours and is subsequently evaporated. The remaining crystalline product is washed with propanol and dried.

後処理

  1. additionis added to the solution
  2. customis subsequently evaporated
  3. washThe remaining crystalline product is washed with propanol
  4. customdried

出典と根拠

ORDレコード
ord-c451687bab2a46079dfc833dbed04ae3
出典データセット
uspto-grants-2014_11
特許番号
US08877799B2

関連ノート

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