Hydrochloric Acid → 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-furan-2-yl-1H-pyrazole-3-carboxylic acid

HRID 33249

反応式

C([O:3][C:4]([C:6]1[CH:10]=[C:9]([C:11]2[O:12][CH:13]=[CH:14][CH:15]=2)[N:8]([CH2:16][C:17]2[CH:21]=[C:20]([C:22]3[S:23][C:24]([Cl:27])=[CH:25][CH:26]=3)[O:19][N:18]=2)[N:7]=1)=[O:5])C.Cl>C1COCC1.O.[OH-].[Na+]>[Cl:27][C:24]1[S:23][C:22]([C:20]2[O:19][N:18]=[C:17]([CH2:16][N:8]3[C:9]([C:11]4[O:12][CH:13]=[CH:14][CH:15]=4)=[CH:10][C:6]([C:4]([OH:5])=[O:3])=[N:7]3)[CH:21]=2)=[CH:26][CH:25]=1

参加物

実験手順

To a solution of 400 mg 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-furan-2-yl-1H-pyrazole-3-carboxylic acid ethyl ester in 5 ml THF and 1 ml water, 1 ml aqueous NaOH (1M) were added and the mixture was stirred for 16 h at RT. Then the solution was acidified to pH 3 with half concentrated hydrochloric acid to precipitate the pure product, which was collected by filtration. Yield: 360 mg.

後処理

customto precipitate the pure product, which
filtrationwas collected by filtration

出典と根拠

ORDレコード: ord-8b3cc6a0b9da435da253f01bb3052e09
出典データセット: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07429581B2

反応式

参加物

反応物 2

生成物 1

試薬・触媒・溶媒 3

実験手順

後処理

出典と根拠

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