反応式
C([O:3][C:4]([C:6]1[CH:10]=[C:9]([CH2:11][OH:12])[N:8]([CH2:13][C:14]2[CH:18]=[C:17]([C:19]3[S:20][C:21]([Cl:24])=[CH:22][CH:23]=3)[O:16][N:15]=2)[N:7]=1)=[O:5])C.[OH-].[Na+].Cl>C1COCC1.O>[Cl:24][C:21]1[S:20][C:19]([C:17]2[O:16][N:15]=[C:14]([CH2:13][N:8]3[C:9]([CH2:11][OH:12])=[CH:10][C:6]([C:4]([OH:5])=[O:3])=[N:7]3)[CH:18]=2)=[CH:23][CH:22]=1参加物
6
反応物 3
生成物 1
試薬・触媒・溶媒 2
実験手順
To a solution of 380 mg 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-hydroxymethyl-1H-pyrazole-3-carboxylic acid ethyl ester in 5 ml THF and 5 ml of water 3 ml of a 1M NaOH were added and the reaction mixture was stirred for 3 h at RT. Then the mixture was acidified with half concentrated hydrochloric acid to pH 3 and the precipitate collected by filtration and washed with 10 ml water. The product was obtained as a white solid which was dried under reduced pressure. Yield: 320 mg.
後処理
- filtrationthe precipitate collected by filtration
- washwashed with 10 ml water
- customThe product was obtained as a white solid which
- customwas dried under reduced pressure
出典と根拠
- ORDレコード
- ord-6ec451a002bd442998dab4f0b476b853
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07429581B2
関連ノート
読み込み中…