Sulfuric Acid → HCID 86685628、化合物

HRID 332837

反応式

HRID 332837 の反応式
Cl[C:2]1[N:7]=[C:6]([NH:8][C@@H:9]2[CH2:14][CH2:13][CH2:12][CH2:11][C@@H:10]2[NH:15]C(=O)[O-])[CH:5]=[N:4][C:3]=1[C:19]#[N:20].[F:21][C:22]1[CH:23]=[N:24][CH:25]=[C:26]([NH2:28])[CH:27]=1.C(=O)([O-])[O-:30].[Cs+].[Cs+].C1C=CC(P(C2C(C3C(P(C4C=CC=CC=4)C4C=CC=CC=4)=CC=C4C=3C=CC=C4)=C3C(C=CC=C3)=CC=2)C2C=CC=CC=2)=CC=1.OS(O)(=O)=O>O1CCOCC1.C(O)(C(F)(F)F)=O.O.CC([O-])=O.CC([O-])=O.[Pd+2]>[NH2:15][C@H:10]1[CH2:11][CH2:12][CH2:13][CH2:14][C@H:9]1[NH:8][C:6]1[N:7]=[C:2]([NH:28][C:26]2[CH:25]=[N:24][CH:23]=[C:22]([F:21])[CH:27]=2)[C:3]([C:19]([NH2:20])=[O:30])=[N:4][CH:5]=1

参加物

10

反応物 5

HCID 1118Sulfuric AcidHCID 10796Cesium carbonateHCID 5744505-Fluoro-3-pyridinamineHCID 634876Binap, (A+-)-HCID 86685625HCID 86685625、化合物

生成物 1

HCID 86685628HCID 86685628、化合物収率 85.8%

試薬・触媒・溶媒 4

HCID 167845palladium(II) acetate触媒HCID 962Water溶媒HCID 6422Trifluoroacetic acid溶媒HCID 312751,4-Dioxane溶媒

反応条件

温度
110 °C

実験手順

The mixture of tert-tutyl ((1S,2R)-2-((6-chloro-5-cyanopyrazin-2-yl)amino)cyclohexyl)carbamate (100 mg, 0.28 mmol), 3-fluoro-5-aminopyridine (60 mg, 0.56 mmol), powder cesium carbonate (360 mg, 1.12 mmol), BINAP (37 mg, 0.06 mmol), Pd(OAc)2 (14 mg, 0.06 mmol) in 20 mL dioxane was degassed with argon stream. It was stirred in argon atmosphere at 110° C. for 2 h. The mixture was cooled, diluted with 100 mL EtOAc, vigorously stirred, and filtered through celite. The filtrate was concentrated and subjected to silica flash column with 0-60% EtOAc in hexane to isolate the coupling product. It was then stirred in 6 mL TFA and 1 mL conc. H2SO4 at 80° C. for 30 m. It was cooled in ice bath, diluted with water, filtered, and subjected to reverse phase preparative HPLC to isolate the title compound (83 mg). MS found for C16H20FN7O as (M+H)+ 346.5. UV: λ=259, 301 nm. 1H NMR: (CD3OD) δ 9.04 (1H, m), 8.57 (1H, m), 8.40 (1H, m), 7.73 (1H, s), 4.49 (1H, m), 3.74 (1H, m), 1.96-1.60 (8H, m) ppm.

後処理

  1. customwas degassed with argon stream
  2. temperatureThe mixture was cooled
  3. additiondiluted with 100 mL EtOAc
  4. stirringvigorously stirred
  5. filtrationfiltered through celite
  6. concentrationThe filtrate was concentrated
  7. customto isolate the coupling product
  8. customat 80° C.
  9. temperatureIt was cooled in ice bath
  10. filtrationfiltered

出典と根拠

ORDレコード
ord-29df8ee851fc429f83591399850729bf
出典データセット
uspto-grants-2014_11
特許番号
US08877760B2

関連ノート

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