4-Iodobenzoyl chloride → HCID 68861098、化合物

HRID 333124

反応式

HRID 333124 の反応式
[NH2:1][C:2]1[S:6][C:5]([S:7]([NH2:10])(=[O:9])=[O:8])=[N:4][N:3]=1.[I:11][C:12]1[CH:20]=[CH:19][C:15]([C:16](Cl)=[O:17])=[CH:14][CH:13]=1>N1C=CC=CC=1>[I:11][C:12]1[CH:20]=[CH:19][C:15]([C:16]([NH:1][C:2]2[S:6][C:5]([S:7](=[O:9])(=[O:8])[NH2:10])=[N:4][N:3]=2)=[O:17])=[CH:14][CH:13]=1

参加物

4

反応物 2

HCID 743734-Iodobenzoyl chlorideHCID 847245-Amino-1,3,4-thiadiazole-2-sulfonamide

生成物 1

HCID 68861098HCID 68861098、化合物収率 13.3%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

To a solution of 5-amino-1,3,4-thiadiazole-2-sulfonamide (0.133 g, 0.50 mmol) in pyridine (5.0 mL) was added 4-iodobenzoyl chloride (0.162 g, 0.75 mmol). The reaction mixture was stirred at room temperature for overnight under nitrogen. Solvent was concentrated and water (60 mL) was added the mixture. The precipitated sulfonamide was filtered and dried over vacuum to give desired compound (27.3 mg, 13%) as a white solid.

後処理

  1. concentrationSolvent was concentrated
  2. additionwater (60 mL) was added the mixture
  3. filtrationThe precipitated sulfonamide was filtered
  4. customdried over vacuum

出典と根拠

ORDレコード
ord-250ae31a92204fd3b323f242a4f44623
出典データセット
uspto-grants-2014_11
特許番号
US08877970B2

関連ノート

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