Iodoethane → 6-ethyl-7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one

HRID 333415ノート

反応式

HRID 333415 の反応式
[O:1]=[C:2]1[N:7]2[CH:8]=[N:9][CH:10]=[C:6]2[CH2:5][CH2:4][NH:3]1.[H-].[Na+].I[CH2:14][CH3:15]>CN(C=O)C>[CH2:14]([N:3]1[CH2:4][CH2:5][C:6]2=[CH:10][N:9]=[CH:8][N:7]2[C:2]1=[O:1])[CH3:15]

参加物

5

反応物 3

HCID 6340IodoethaneHCID 24758Sodium hydrideHCID 14875185H,6H,7H,8H-imidazo(1,5-c)pyrimidin-5-one

生成物 1

HCID 126472846-ethyl-7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To 500 mg (3.6 mmol) of 5,6,7,8-tetrahydro-5-oxoimidazo[1,5-c]pyrimidine dissolved in 5 mL of DMF are added cautiously at room temperature 173 mg (4.32 mmol) of sodium hydride. The reaction medium is stirred for 1 hour at room temperature, and 0.35 mL (4.32 mmol) of iodoethane is then added dropwise. The reaction medium is stirred for 2 hours at room temperature and the solvents are then evaporated off. The residue is treated with 1N NaHCO3 solution and extracted with chloroform. The combined organic phases are dried with MgSO4, filtered and evaporated. The oil obtained is used directly in the following step.

後処理

  1. stirringThe reaction medium is stirred for 2 hours at room temperature
  2. customthe solvents are then evaporated off
  3. additionThe residue is treated with 1N NaHCO3 solution
  4. extractionextracted with chloroform
  5. dry with materialThe combined organic phases are dried with MgSO4
  6. filtrationfiltered
  7. customevaporated
  8. customThe oil obtained

出典と根拠

ORDレコード
ord-b9fc3996d22b4207a971a1dc312ba64b
出典データセット
uspto-grants-2014_11
特許番号
US08877968B2

反応ノート

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