Lithium Hydroxide → HCID 178463865、化合物

HRID 333418ノート

反応式

HRID 333418 の反応式
[CH2:1]([N:3]([CH2:21][CH2:22][C:23]1[N:24]=[CH:25][NH:26][CH:27]=1)[C:4](=[O:20])[NH:5][C@@H:6]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=1)[C:7]([O:9]C)=[O:8])[CH3:2].[OH-].[Li+]>C1COCC1.O>[CH2:1]([N:3]([CH2:21][CH2:22][C:23]1[N:24]=[CH:25][NH:26][CH:27]=1)[C:4](=[O:20])[NH:5][CH:6]([CH2:11][C:12]1[CH:13]=[CH:14][C:15]([O:18][CH3:19])=[CH:16][CH:17]=1)[C:7]([OH:9])=[O:8])[CH3:2]

参加物

5

反応物 2

HCID 3939Lithium HydroxideHCID 178463866HCID 178463866、化合物

生成物 1

HCID 178463865HCID 178463865、化合物収率 69.4%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

反応条件

温度
100 °C

実験手順

150 mg (0.4 mmol) of methyl(S)-2-{3-ethyl-3-[2-(1H-imidazol-4-yl)ethyl]ureido}-3-(4-methoxyphenyl)propionate are diluted in 4 mL of THF and 1 mL of water, and 150 mg (6 mmol) of lithium hydroxide are added. The mixture is heated for 10 minutes at 100° C. in a microwave reactor. The solvents are evaporated off and the residue is then purified on a pad of silica (eluent: 1/1 dichloromethane/methanol). 100 mg of 2-{3-ethyl-3-[2-(1H-imidazol-4-yl)ethyl]ureido}-3-(4-methoxyphenyl)propionic acid in the form of a pale yellow powder are obtained in a yield of 69%.

後処理

  1. customThe solvents are evaporated off
  2. customthe residue is then purified on a pad of silica (eluent: 1/1 dichloromethane/methanol)

出典と根拠

ORDレコード
ord-693d2af3870b46c687b562cc960d4560
出典データセット
uspto-grants-2014_11
特許番号
US08877968B2

反応ノート

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