Isopropylamine → 3-Chloro-N-(propan-2-yl)pyrazin-2-amine
反応式
Cl[C:2]1[C:7]([Cl:8])=[N:6][CH:5]=[CH:4][N:3]=1.[CH3:9][CH:10]([NH2:12])[CH3:11]>C1COCC1>[Cl:8][C:7]1[C:2]([NH:12][CH:10]([CH3:11])[CH3:9])=[N:3][CH:4]=[CH:5][N:6]=1参加物
4
実験手順
2,3-dichloropyrazine (10 g, 67.1 mmol), propan-2-amine (11.90 g, 201 mmol), and 50 mL of THF were mixed in a three-neck flask and stirred at room temperature overnight. The reaction was brought to reflux overnight. The reaction was cooled and the solvent was evaporated. The residue was dissolved in dichloromethane and the salt was filtered. The solvent was then evaporated and the residue was purified by column using dichloromethane as solvent to give 3-chloro-N-isopropylpyrazin-2-amine (6.2 g, 53.8%).
後処理
- temperatureto reflux overnight
- temperatureThe reaction was cooled
- customthe solvent was evaporated
- dissolutionThe residue was dissolved in dichloromethane
- filtrationthe salt was filtered
- customThe solvent was then evaporated
- customthe residue was purified by column
出典と根拠
- ORDレコード
- ord-2f52f21493e84c5caa5d10d5da1134e0
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08883322B2
反応ノート
読み込み中…