1,1-Dichloroethane → 7-(Benzyloxy)-5-(chloroacetyl)quinolin-2(1H)-one

HRID 33382

反応式

HRID 33382 の反応式
[C:1]([C:4]1[CH:13]=[C:12]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][C:8](=[O:22])[NH:9]2)(=[O:3])[CH3:2].I([Cl:26])(=O)=O.I(Cl)(=O)=O.C([N+](C)(C)C)C1C=CC=CC=1.ClC(Cl)C.C(=O)([O-])[O-].[Na+].[Na+].S([O-])([O-])=O.[Na+].[Na+]>C(O)(=O)C.O>[CH2:15]([O:14][C:12]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8](=[O:22])[NH:9]2)=[C:4]([C:1](=[O:3])[CH2:2][Cl:26])[CH:13]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

参加物

8

反応物 5

HCID 63651,1-DichloroethaneHCID 10340Sodium CarbonateHCID 24437Sodium SulfiteHCID 210728495-Acetyl-7-(benzyloxy)quinolin-2(1H)-oneHCID 56924451Trimethylbenzylammonium Dichloroiodate

生成物 1

HCID 210728597-(Benzyloxy)-5-(chloroacetyl)quinolin-2(1H)-one

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 962Water溶媒

実験手順

7.0 g (23.9 mmol) 5-acetyl-7-benzyloxy-1H-quinolin-2-one and 19.0 g (54.6 mmol) benzyltrimethylammonium dichloriodate are stirred in 43 mL acetic acid, 7 mL water and 147 mL dichloroethane at 65° C. After 4.5 hours the raction is stopped by the addition of 400 mL sodium carbonate solution and 50 mL 5% sodium sulphite solution. The insoluble constituents are suction filtered, washed with water and dried.

後処理

  1. customat 65° C
  2. washwashed with water
  3. customdried

出典と根拠

ORDレコード
ord-3f80127dda564470b49deac0d92492bf
出典データセット
uspto-grants-2008_09
特許番号
US07429583B2

関連ノート

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