Sodium Hydroxide → 1-(3-Chlorophenyl)-1H-1,2,4-triazole-3-carboxylic acid

HRID 334009ノート

反応式

HRID 334009 の反応式
C[O:2][C:3]([C:5]1[N:9]=[CH:8][N:7]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[CH:11]=2)[N:6]=1)=[O:4].[OH-].[Na+]>C1COCC1.O>[Cl:16][C:12]1[CH:11]=[C:10]([N:7]2[CH:8]=[N:9][C:5]([C:3]([OH:4])=[O:2])=[N:6]2)[CH:15]=[CH:14][CH:13]=1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 694601791-(3-chlorophenyl)-1H-1,2,4-triazole-3-carboxylic acid methyl ester

生成物 1

HCID 713019271-(3-Chlorophenyl)-1H-1,2,4-triazole-3-carboxylic acid

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒2 回

実験手順

14.8 g (62.3 mmol) 1-(3-chloro-phenyl)-1H-[1,2,4]-triazole-3-carboxylic acid methyl ester was taken up in 70 mL THF and treated with 40 mL 4M aqueous NaOH solution at RT for 12 h. The reaction mixture was diluted with water, THF was removed by distillation, ice water was added and the mixture was acidified with 4 M aqueous HCl solution. The precipitated was filtered off, washed with water and triturated with diethyl ether.

後処理

  1. customwas removed by distillation, ice water
  2. additionwas added
  3. filtrationThe precipitated was filtered off
  4. washwashed with water
  5. customtriturated with diethyl ether

出典と根拠

ORDレコード
ord-e4d67e829e2d4b528419bf968f0a800a
出典データセット
uspto-grants-2014_11
特許番号
US08883789B2

反応ノート

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