Water → 2-(3-Chloro-phenyl)-2H-tetrazole-5-carboxylic acid
反応式
C([O:3][C:4]([C:6]1[N:7]=[N:8][N:9]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[CH:12]=2)[N:10]=1)=[O:5])C.O.[Li+].[OH-]>C1COCC1>[Cl:17][C:13]1[CH:12]=[C:11]([N:9]2[N:8]=[N:7][C:6]([C:4]([OH:5])=[O:3])=[N:10]2)[CH:16]=[CH:15][CH:14]=1参加物
5
実験手順
7.00 g (27.7 mmol) 2-(3-chloro-phenyl)-2H-tetrazole-5-carboxylic acid ethyl ester was dissolved in 50 mL THF and 50 mL water and treated with 2.33 g (55.4 mmol) LiOH at RT for 14 h. The reaction mixture was concentrated and acidified with 1 M aqueous hydrochlorid acid. The precipitate was filtered off, washed with water and dried.
後処理
- concentrationThe reaction mixture was concentrated
- filtrationThe precipitate was filtered off
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-411eb9e1998e45fa822c29f3798f8244
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08883789B2
反応ノート
読み込み中…