Hydrochloric Acid → 5-Bromo-methyl-benzofuran-3-carboxylic acid
反応式
C[O:2][C:3]([C:5]1[C:9]2[CH:10]=[C:11]([Br:14])[CH:12]=[CH:13][C:8]=2[O:7][C:6]=1[CH3:15])=[O:4].[Li+].[OH-].Cl>C1COCC1>[Br:14][C:11]1[CH:12]=[CH:13][C:8]2[O:7][C:6]([CH3:15])=[C:5]([C:3]([OH:4])=[O:2])[C:9]=2[CH:10]=1参加物
5
実験手順
350 mg (1.30 mmol) 5-bromo-2-methyl-benzofuran-3-carboxylic acid methyl ester was dissolved in 10 mL THF and treated with 5.0 mL 1 M aqueous LiOH solution at 60° C. for 12 h. The reaction mixture was acidified with 1 M aqueous hydrochlorid acid. The precipitate was filtered off, washed with water and dried.
後処理
- filtrationThe precipitate was filtered off
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-721f72cc2ab345f18d94b62a8a11d0e1
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08883789B2
反応ノート
読み込み中…